Significant Achievement of Associate Processor Wang Haoran from SMBU Faculty of Materials Science Published in Chemical Society Reviews (IF=40.4)

Associate Processor Wang Haoran from SMBU Faculty of Materials Science has recently published a review paper titled “Intracellular aggregation of exogenous molecules for biomedical applications” in the world-famous journal Chemical Society Reviews (DOI: 10.1039/d5cs00141b), with Associate Processor Wang Haoran as the corresponding author and the co-first author, and Academician Tang Benzhong from Chinese University of Hong Kong (Shenzhen), Processor Xu Wanhai from Harbin Medical University and Processor Cheng Dongbing from Wuhan University of Technology as co-corresponding authors. This paper reveals the aggregation mechanism of exogenous molecules in cells, providing new solutions for cancer treatment and precise imaging.

With focus on aggregation of exogenous molecules in cells, this paper leveraged cellular microenvironment (such as pH, redox state and enzymatic activity) or extrinsic stimulus (light and temperature) to control the aggregation, solving core problems in disease diagnosis and treatment, and provided precise strategies for tumor therapy, bioimaging and immunomodulation through the molecular design for controllable aggregation. This paper discussed the core aggregation mechanisms in cells, including those induced by cellular microenvironment, extrinsic stimulus and organelle, and the biomedical application scenarios including life process exploration and disease diagnosis, cell fate manipulation and treatment, and analyzed the challenges and further trends of this field.

This review paper symmetrically integrated the aggregation mechanisms of exogenous molecules in cells with frontier applications, demonstrating its potential in the precision medicine, and providing the theoretical framework and technical path for the development of intelligent biological materials and novel diagnostic reagents. In future, through the cross-discipline innovation, the intracellular aggregation technologies are expected to drive the treatment innovation for cancer, neurodegeneration and other diseases.

Since joining in Shenzhen MSU-BIT University, Associate Processor Wang Haoran has published 6 SCI papers as the first corresponding author with Shenzhen MSU-BIT University as the first corresponding institution, including one in Chemical Society Reviews (IF=40.4), one in Chem (IF=19.1), one in ACS Nano (IF=17.1), one in Aggregate (IF=13.9), and two in Advanced Optical Materials (IF=8.2), and obtained systematic achievements in the mechanism and biological application of aggregation science.

Link to the paper:

https://pubs.rsc.org/en/content/articlelanding/2025/cs/d5cs00141b